COVID-19对甲状腺功能的影响:来自伊朗的证据
M Yadollahzadeh1, S Shakeri1, I Heydari2
1Iran University of Medical Sciences, Firoozgar Medical and Educational Hospital, Department of Internal Medicine, Tehran, Iran.
Acta endocrinologica (Bucharest, Romania : 2005)
|August 21, 2023
概括
COVID-19的严重程度与甲状腺功能障碍相关,特别是甲状腺刺激激素 (TSH). 在严重的COVID-19患者中,较高的乳酸脱酶 (LDH) 水平与较低的TSH有关,这表明潜在的甲状腺炎症标志物连接.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 临床化学 临床化学
背景情况:
- 全球大流行COVID-19已与各种系统性并发症有关.
- 甲状腺功能障碍越来越被认为是病毒感染的潜在并发症.
- 了解COVID-19严重程度,甲状腺激素和炎症之间的相互作用对于患者管理至关重要.
研究的目的:
- 为了调查COVID-19严重程度和甲状腺功能之间的关联.
- 在COVID-19患者中探索甲状腺激素和炎症标志物之间的关系.
主要方法:
- 一项涉及95名COVID-19患者的观察性研究.
- 测量甲状腺刺激激素 (TSH),甲状腺素,三甲状腺素,C反应蛋白,红细胞沉积率,乳酸脱酶 (LDH) 和淋巴细胞.
- 使用t测试,非参数测试和斯皮尔曼相关性进行统计分析.
主要成果:
- 甲状腺功能障碍的增加趋势,特别是TSH,与COVID-19严重程度的进展一起观察到,尽管在统计学上并不显著.
- 在TSH和LDH之间发现了显著的逆斯皮尔曼相关性 (r=-0.28).
- 证实了COVID-19严重程度和LDH水平 (p<0.001) 之间存在直接关联.
结论:
- 在COVID-19的严重程度和LDH水平之间存在直接关系.
- 在LDH水平和TSH之间观察到反向关联,这表明COVID-19中炎症和甲状腺功能之间存在联系.
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