25氧维生素D与膝关节骨关节炎之间的关系:随机对照试验的系统审查和元分析
Rui Wang1,2, Zheng-Ming Wang3, Si-Cheng Xiang4
1Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in medicine
|August 21, 2023
概括
维生素D补充改善了膝关节骨关节炎症状,包括疼痛和功能. 它也对突液和带软骨产生了积极的影响,尽管关节空间宽度和骨髓病变没有受到影响.
科学领域:
- 整形外科 整形外科 整形外科
- 类风湿病学 类风湿病学
- 营养科学 营养科学
背景情况:
- 膝关节骨关节炎 (KOA) 是一种普遍存在的退行性关节疾病.
- 维生素D在KOA病原和治疗中的作用仍在研究中.
- 了解维生素D对KOA的影响可能会提供新的治疗策略.
研究的目的:
- 对调查25-基维生素D和KOA之间的关系的随机对照试验 (RCT) 进行元分析.
- 评估在被诊断为KOA的患者中补充维生素D的疗效.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了系统的文献搜索.
- 包含的RCT重点关注KOA患者的维生素D补充与安慰剂.
- 评估的结果包括带软骨体积,关节空间宽度 (JSW),突液体体积和WOMAC评分.
主要成果:
- 维生素D补充剂显著影响了突液体体积,视觉模拟尺度 (VAS) 疼痛评分和带软骨.
- 在WOMAC的疼痛和功能分量表中观察到统计学上显著的改善,但在刚性分量表中没有.
- 没有发现对骨髓病变或关节空间宽度直径的显著影响.
- 一个小组分析表明,每日剂量>2,000 IU的维生素D减缓了突组织的发育.
结论:
- 维生素D补充剂对因KOA而经历膝盖不适和功能限制的个体产生有益影响.
- 进一步的研究可能会阐明最佳的维生素D剂量及其在KOA管理中的特定机制.
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