队列资料更新:科克和克里糖尿病和心脏病研究
Danko Stamenic1, Janas M Harrington1, Seán R Millar1
1School of Public Health, University College Cork, Cork, Co. Cork, Ireland.
HRB open research
|August 21, 2023
概括
科克和凯里糖尿病和心脏病研究的复查发现高血压率,并将肠道微生物群多样性与爱尔兰成年人的代谢健康联系起来. 它还确定了老年初级保健患者可能不适当的处方.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 科克和克里糖尿病和心脏病研究调查了爱尔兰中年成年人的心血管疾病和糖尿病.
- 米切尔斯敦队列最初在2010-2011年间从一家初级保健中心招募.
- 2015年对这一队列进行了后续重新选.
研究的目的:
- 评估Mitchelstown队列中心血管疾病和相关风险因素的患病率.
- 纳入新的措施,包括认知,虚弱,药物坚持,饮食和肠道微生物组分析.
- 分析处方模式及其与初级保健中的健康结果的关联.
主要方法:
- 数据收集包括心血管健康指标,风险因素,认知,脆弱性,药物坚持和饮食信息.
- 收集便样本进行RNA测序,以分析肠道微生物组.
- 随着时间的推移,对处方数据进行了分析,以确定可能不适当的处方.
主要成果:
- 再次查实现了76.1%的响应率与原始队列相比,有1378名参与者年龄在51-77岁之间.
- 高血压的患病率很高 (50-64%).
- 在代谢健康的非肥胖个体中观察到更大的肠道微生物群多样性;在老年人中,可能存在不适当的处方.
结论:
- 复查提供了对研究人口中心血管健康和相关因素的宝贵见解.
- 该研究的初级保健环境通过电子健康记录促进了被动的随访.
- 所有收集的数据都存储在科克大学学院,欢迎未来的研究合作.
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