在中年和老年人中,欧米茄-3指数,心肺健康和认知功能
Kimberly N Doughty1, Juliana Blazek2, David Leonard2
1Marion Peckham Egan School of Nursing & Health Studies, Fairfield University, Fairfield, CT, USA.
Preventive medicine reports
|August 21, 2023
概括
较高的omega-3指数和心肺呼吸能力与更好的认知功能有关. 低心肺呼吸能力,独立于omega-3水平,显著增加了老年人认知障碍的风险.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 欧米茄-3脂肪酸水平 (欧米茄-3指数,O3I) 和心肺健康 (CRF) 独立地与减少认知障碍有关.
- 有限的研究已经探索了O3I和CRF对老年人认知功能的联合影响.
研究的目的:
- 在健康的老年人中调查omega-3指数 (O3I),心肺健康 (CRF) 和认知障碍之间的关系.
- 为了确定CRF是否会改变O3I与认知功能之间的关联.
主要方法:
- 对5464名年龄在55-85岁之间的健康个体进行了横截面分析.
- 的O3I分类为<4.0%,4.0-7.9%,或≥8.0%.
- 慢性肺炎被分为五分之一 (低,中等,高).
- 以蒙特利尔认知评估得分定义的认知障碍 ≤25.
- 普森回归用于估计认知障碍的相对风险 (RR),控制共变量和CRF.
主要成果:
- 低O3I (<4.0%) 最初与增加的认知障碍有关,但在调整CRF后,这并不显著.
- 低CRF独立地与较高的认知障碍风险相关 (RR,1.28;95% CI,1.07-1.53),不论O3I.
- 对于认知障碍风险,CRF和O3I之间没有发现显著的相互作用.
- 较低O3I或较低CRF或两者都观察到认知障碍的风险增加.
结论:
- 心肺健康似乎是比这个队列中的omega-3指数更强大的认知功能的独立预测指标.
- 保持较高的CRF对于保持老年人的认知健康至关重要.
- 需要进一步的研究来阐明O3I,CRF和不同人群的认知功能之间的复杂相互作用.
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