在迦纳的一个城市设施中,在状细胞危机中对阿片类药物使用的比较分析
Marian Opoku-Agyakwa1, Henry J Lawson2, Edeghonghon Olayemi3
1Family Medicine Department University of Ghana Medical Centre Accra Ghana.
EJHaem
|August 21, 2023
概括
吗啡在状细胞病患者的血管封闭性危机 (VOC) 中提供了比pethidine更快的疼痛反应. 这两种阿片类药物表现出相似的耐受性和副作用概况,没有观察到呼吸抑制.
科学领域:
- 疼痛管理 疼痛管理
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 血管封闭性危机 (VOC) 是状细胞病的常见并发症.
- 阿片类药物是管理VOC疼痛的主要治疗方法.
- 腹腔丁和吗啡经常被使用,因此需要对它们的疗效和安全性进行比较.
研究的目的:
- 为了比较静脉注射吗啡与肌内丁在急性血管闭塞危机期间减轻疼痛的疗效.
- 评估持续疼痛反应的时间和整体足够的疼痛控制.
- 在状细胞病患者中评估这两种阿片类药物的耐受性和副作用概况.
主要方法:
- 这是一项开放式的随机研究,涉及82名成人状细胞疾病参与者.
- 参与者接受了静脉注射吗啡 (每4小时5毫克) 或肌肉内佩提丁 (每4小时75毫克).
- 监测了疼痛反应,足够控制疼痛的时间和副作用.
主要成果:
- 在接受吗啡 (53.7%) 的参与者中,在6小时内获得持续疼痛反应的比例明显高于接受丁的参与者 (31.7%) (p=0.027).
- 在62.5%的吗啡接受者和60.0%的佩提丁接受者 (p=0.296) 中,在72小时内实现了足够的疼痛控制.
- 大多数参与者 (96.3%) 没有出现显著的副作用;最常见的是,恶心,吐和头痛. 佩提丁组的副作用发生率略高 (29.3%) 与吗啡 (22.0%) (p=0.448) 相比.
结论:
- 静脉注射吗啡在实现持续疼痛反应方面表现出优异的疗效,与急性血管闭塞危机的肌肉内丁相比.
- 吗啡和丁都表现出可比的耐受性和副作用概况.
- 两种阿片类药物都没有导致呼吸抑制,这凸显了它们在这种情况下的相对安全性.
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