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在ENDS产品中对缺少数据的模拟漏性化合物的评估的分析方法:一个案例研究

Cameron Smith¹, Matthew Lyndon¹, Lena Jeong¹

¹Juul Labs Inc., Washington, DC, United States.

Frontiers in chemistry

|August 21, 2023

概括

在电子尼古丁输送系统 (ENDS) 中调查可泄露化合物至关重要. 一种新的分析方法估计,缺乏数据的化合物的转移效率在ENDS气溶中低于2%,有助于毒理风险评估.

科学领域:

分析化学分析化学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

透性调查评估从容器封闭系统转移到产品中的化学物质.
电子尼古丁输送系统 (ENDS) 缺乏特定的可漏性研究指南,需要从口服吸入药物产品指南中进行调整.
在模拟的ENDS研究中发现了两种缺少数据的漏性化合物.

研究的目的:

开发和应用一种新的分析方法来量化ENDS气溶中缺少数据的可漏化合物.
为了确定这些可浸出化合物的从电子液体到气溶的转移效率.
通过建立相关的暴露限值,支持对ENDS的毒理风险评估.

主要方法:

模拟的可漏性研究使用老年JUULpods与无味电子液体.
使用液体染色学-质谱学/质谱学 (LC-MS/MS) 的定性气溶分析.
开发一种替代方法,以确定缺乏数据的化合物的方法极限,包括使用增值样本确定量化的极限.

主要成果:

定性气溶分析没有检测到漏性目标化合物的痕迹.
另一种方法为缺少数据的可浸化合物确定了保守的半定量值.
通过实验确定了可浸化合物的从电子液体到气溶的转移效率不到2%.

结论:

成功开发了一种新的分析方法,以估计ENDS气溶中缺少数据的可漏化合物的转移效率.
低转移效率 (<2%) 为在毒理风险评估中定义暴露限值提供了基础.
该方法解决了ENDS安全评估中的一个关键缺口,特别是对于毒理学数据有限的化合物.

关键词:

结局结束结束气溶喷雾剂是一种气溶.电子烟是一种电子烟.电子烟电子烟是一种电子烟.浸泡物质是可以浸泡的.尼古丁是一种尼古丁.风险评估风险评估风险评估

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