后急性感染综合征 (PAIS) 中的微生物组
Cheng Guo1, Boyang Yi2, Jianyong Wu3
1Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, USA.
Computational and structural biotechnology journal
|August 21, 2023
概括
后急性感染综合征 (PAIS) 涉及感染后的长期症状. 本综述探讨了肠道和口腔微生物组的变化如何可能导致PAIS,包括PASC和ME/CFS等疾病.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 后急性感染综合征 (PAIS) 涵盖了各种感染后的长期症状.
- 像COVID-19 (PASC) 后急性后果和肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 这样的疾病是PAIS的重要例子.
- 症状和感染史上的相似性表明PAIS的共同潜在原因.
研究的目的:
- 对感染和PAIS患者口腔和肠道微生物群变化的研究进行审查和综合.
- 讨论将微生物组失调与PAIS发展联系在一起的理论.
- 探索微生物组在PAIS病变发生过程中的机械作用和潜在功能.
主要方法:
- 在传染病和PAIS条件下对口腔和肠道微生物群的研究文献综述.
- 分析提出的病因理论,将微生物组变化与PAIS联系起来.
- 识别知识缺口和潜在的临床应用.
主要成果:
- 微生物群失生症经常在患有各种感染和PAIS的患者中观察到.
- 该审查强调了微生物组变化和PAIS症状之间的合理机制联系.
- 特定的微生物特征和功能与PAIS的发展有关.
结论:
- 人类微生物组在PAIS的发展和进展中起着至关重要的作用.
- 了解微生物组失生症为PAIS的预防和治疗提供了潜在的治疗点.
- 需要进一步的研究来阐明特定的微生物机制,并开发临床干预措施.
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