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在叶中小脑的结构和功能变化

Ge Wang^1,2,3, Xianghe Liu^1,2,3, Min Zhang^1,2,3

¹Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Frontiers in neurology

|August 21, 2023

概括

叶 (TLE) 与小脑结构变化和功能连接的改变有关. 这些小脑变化,特别是微观结构变化,与海马硬化和特定的发作类型有关,影响认知功能.

科学领域:

神经成像是一种神经成像.
的研究研究.
小脑神经科学是神经科学.

背景情况:

(TLE) 是一种常见的神经疾病,通常与认知缺陷有关.
小脑在TLE病理生理学中的作用越来越被认可,但尚未完全理解.
研究小脑的结构和功能变化对于全面了解TLE至关重要.

研究的目的:

探索TLE中小脑的结构和功能变化.
为了将这些小脑变化与临床信息相关联,包括海马硬化症 (HS) 和焦点到双边强力-克隆性 (FBTCS).
检查TLE中小脑-大脑功能连接 (FC) 模式.

主要方法:

利用SUIT工具箱进行小脑体积和扩散张力图像分析.
进行了基于种子的全脑分析,以评估小脑-大脑功能连接 (FC).
根据HS,FBTCS和的横向化进行了子组分析.

主要成果:

在TLE患者中观察到特定小脑区域 (crusII,VIIb,VIIIb,crusI,VIIIa) 的灰质缩.
在小脑 afferent 脚中检测到扩散异常,表明微观结构变化.
发现右角II和左侧准海马皮层之间减少了FC,以及左叶片VI-VIII和注意力/视觉网络之间增加了FC;减少的FC与较差的认知相关,而增加的FC则建议补偿.

结论:

TLE的特征是小脑的微观结构变化,特别是在HS和FBTCS患者中.
在TLE中改变小脑-大脑功能连接与认知障碍有关.
大脑小脑结构变化与HS/FBTCS有关,而FC变化在TLE子组中广泛存在.

关键词:

小粒小脑的脚.小脑小脑是什么意思功能连接性的功能连接性多模式核磁共振成像 (MRI)在叶发作.

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