泰拉西米亚携带者身份和地下水铁:对孟加拉国儿童补充铁计划的实施
Sabuktagin Rahman1, Patricia Lee2, Moududur Rahman Khan3
1Department of Nutrition and Food Engineering, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.
Journal of public health research
|August 21, 2023
概括
在孟加拉国,患有thalassemia的儿童在微量营养素粉末 (MNP) 干预后血红蛋白没有变化. 没有thalassemia的儿童血红蛋白略有增加,这表明MNP在高铁环境中对thalassemia携带者来说更安全.
科学领域:
- 儿科血液学 儿科血液学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 血病是孟加拉国普遍存在的先天性血液疾病,其特点是血红蛋白低,铁含量高.
- 饮用地下水中的高铁含量加剧了孟加拉国人口的铁状况.
- 这项研究调查了含铁微量营养素粉末 (MNP) 对孟加拉国儿童的血红蛋白和费里丁的影响,包括患有血症和没有血症的儿童,考虑到地下水中铁的暴露.
研究的目的:
- 评估含铁微量营养素粉末 (MNP) 对孟加拉患有血病儿童的血红蛋白和费里丁水平的疗效.
- 为了比较MNP对血红蛋白和费里丁在患有thalassemia的儿童及其非thalassemia同龄人的影响.
- 评估MNP干预措施的安全性和影响,对来自地下水的铁暴露率高的人群进行评估.
主要方法:
- 来自MNP疗效试验的2至5岁222名儿童的子样本被查血病.
- 在基线和终点测量了血红蛋白和费里丁水平,无论是血病携带者还是非携带者.
- 来自饮食,地下水和MNP的铁摄入量被量化,通过包括曼·惠特尼和t测试在内的统计分析.
主要成果:
- 患有thalassemia的儿童的血红蛋白水平保持不变 (11.56 g/dL终点与11.6 g/dL基线相比,p=0.83).
- 没有thalassemia儿童的血红蛋白水平呈现上升趋势 (12.54g/dL终点与12.41g/dL基线相比,p=0.06).
- 血病携带者基线铁储量 (594克) 比非携带者 (558克) 高得多,携带者没有显著的费里丁增加 (7.37%,p=0.7),但非携带者显著增加 (10.17%,p=0.009).
结论:
- 孟加拉国地下水中的血病和高铁的共存表明,使用低铁MNP的贫血预防计划可能对血病携带者来说不那么危险.
- 微量营养素干预应考虑目标人群的特定铁状况和遗传倾向.
- 需要进行进一步的研究,以优化MNP配方,以适用于患有特殊健康状况的人群,如沙拉西米亚和高环境铁暴露.
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