孕期糖尿病患者的生长差异化因子-15及其与微专尿的关系
Yinyun Gong1, Jin Shi1, Jing Li2
1Department of Gynecology and Obstetrics, Nantong Haimen People's Hospital, Haimen, Jiangsu 226100, P.R. China.
Experimental and therapeutic medicine
|August 21, 2023
概括
血清生长分化因子-15 (GDF-15) 水平在妊娠期糖尿病 (GDM) 的孕妇中升高. 较高的GDF-15与GDM并发症 (如微专尿症) 有关,这表明它是潜在的预测生物标志物.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 生物标志物发现发现
背景情况:
- 孕期糖尿病 (GDM) 是一种普遍存在的妊娠并发症.
- 增长分化因子-15 (GDF-15) 涉及到各种疾病过程.
- 了解GDF-15在GDM中的作用对于改善患者的治疗结果至关重要.
研究的目的:
- 在患有GDM的患者中检查血清GDF-15水平.
- 确定GDM中GDF-15的临床意义.
- 探索GDF-15作为GDM相关并发症的潜在生物标志物.
主要方法:
- 一组237名孕妇 (20-24周怀孕) 被分为正常怀孕 (70) 和GDM (167) 组.
- 收集了临床数据,包括BMI,葡萄糖水平,HbA1c,胰岛素和尿蛋白.
- 测量血清GDF-15水平并分析相关性和风险因素.
主要成果:
- 在GDM组呈现较高的BMI,禁食血葡萄糖,1小时和2小时的血葡萄糖,糖化血红蛋白,禁食胰岛素和血清GDF-15水平.
- 微专尿在GDM组中更为普遍.
- 血清GDF-15水平与BMI,葡萄糖参数,胰岛素耐药性和禁食胰岛素正相关.
结论:
- 在GDM患者中,血清GDF-15水平显著升高.
- 升高的GDF-15是GDM中微专尿的独立危险因素.
- 在GDM中,GDF-15显示出作为预测GDM中微专尿症的新型生物标志物具有前途.
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