石头,便和尿液微生物组中的罕见类型与尿路结石疾病有关
Mangesh Suryavanshi1, Jose Agudelo1, Aaron Miller1,2
1Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, United States.
Frontiers in molecular biosciences
|August 21, 2023
概括
罕见的微生物在尿路结石病 (USD) 和结石形成中至关重要. 了解这些罕见的类型是开发新的细菌疗法以改善泌尿健康的关键.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 微生物种在复杂的社区中的低丰富性作用正在获得认可.
- 肠道和尿路微生物与尿路结石病 (USD) 有关.
- 结石含有独特的微生物群,但罕见微生物的贡献尚不清楚.
研究的目的:
- 分析罕见和常见类型对尿路结石病的贡献.
- 为了对来自结石,便和尿液样本的16S rRNA数据集进行元分析.
- 了解罕见类型对微生物组结构和USD的影响.
主要方法:
- 16S rRNA基因测序数据的元分析,来自具有和没有USD.的参与者.
- 基于安普利康序列变异频率和丰度的罕见和常见类型的分离.
- 同时发生的相关性分析,以评估微生物社区结构.
主要成果:
- 罕见的类型构成了所有样本类型中的大多数物种,结石显示的罕见性比例最高.
- 罕见和常见的微生物分量都对样本类型之间的差异和健康差异有显著的贡献.
- 尿液和便中的特定罕见类型与USD有显著的关联,罕见类型对石头微生物组结构最为关键.
结论:
- 罕见的类型在尿路结石疾病的病理生理学中起着重要作用,特别是在结石基质内.
- 结石矩阵是一个微生物生物量较低的利基,突出显示了稀有类型的重要性.
- 需要进一步的研究来阐明罕见类型在结石病变发生中的功能作用.
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