META-INSTI:自发不良事件报告中的整合酶链转移抑制剂的使用后代谢不良事件
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Milena M Murray1,2, Lara Fakhouri1, Spencer E Harpe1
1Midwestern University College of Pharmacy, Downers Grove, IL, USA.
Drugs in context
|August 21, 2023
概括
整合酶链转移抑制剂 (INSTIs) 与高血糖症和体重增加等代谢问题有关. 这项研究分析了不良事件报告,发现与特定INSTIs的关联,并推临床监测.
科学领域:
- 药物监督 药物监督 药物监督
- 代谢医学是一种代谢医学.
- 艾滋病毒治疗药物 艾滋病治疗药物
背景情况:
- 整合酶链转移抑制剂 (INSTIs) 是一种关键的抗逆转录病毒药物.
- 以前的报道表明,INSTIs可能有代谢副作用.
- 美国食品和药物管理局的不良事件报告系统 (FAERS) 是药物监测的宝贵资源.
研究的目的:
- 调查INSTI使用与代谢不良事件之间的关联.
- 分析特定的代谢事件,包括高血糖症/新发糖尿病 (H/DM) 和体重增加.
- 为了比较不同INSTI药物的代谢事件风险.
主要方法:
- 用了FAERS数据从2007年第四季度到2019年第四季度的成年报告.
- 通过使用标准化MedDRA查询识别了H/DM病例.
- 分析体重增加作为单独的不良事件.
- 计算报告几率比率 (RORs) 与INSTI类和单个药物的95%信心区间 (CI).
主要成果:
- 审查了超过1010万份FAERS报告,18400所涉及的INST.
- 任何INSTI使用都显示H/DM (1.20) 和体重增加 (2.16) 的ROR增加.
- 比克特格拉维尔和多卢特格拉维尔与H/DM有关,而所有INSTIs都显示体重增加的风险增加.
结论:
- 在INSTI使用和代谢不良事件之间存在潜在的关系,特别是H / DM与bictegravir和 dolutegravir,以及所有INSTIs的体重增加.
- 临床医生应该意识到这些风险,并实施适当的患者监测.
- 进一步的研究可能会阐明这些代谢效应背后的机制.
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