六胺生物合成途径和O-GlcNAc循环糖代谢在脑功能和疾病中的作用

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350

Dong Yeol Kim¹, Jiwon Park¹, Inn-Oc Han¹

¹Department of Biomedical Science, Program in Biomedical Science and Engineering, College of Medicine, Inha University, Incheon, South Korea.

American journal of physiology. Cell physiology

|August 21, 2023

概括

改变大脑葡萄糖代谢和胺生物合成途径 (HBP) 活动会破坏与O相关的N-乙糖胺 (O-GlcNAc) 循环,影响神经元功能和神经退行. 了解O-GlcNAcylated蛋白是治疗大脑疾病的关键.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
细胞生物学细胞生物学

背景情况:

大脑葡萄糖代谢受损与神经退行有关.
破坏胺生物合成途径 (HBP) 和O-链接的N-乙糖胺 (O-GlcNAc) 循环是大脑缺陷的一个新兴因素.
O-GlcNAcylation是一种翻译后的修饰,它调节神经系统中的许多细胞和核蛋白质.

研究的目的:

审查HBP/O-GlcNAcylation在神经系统中的关键作用.
总结O-GlcNAcylated神经元蛋白的功能和调节机制.
探索O-GlcNAcylated蛋白质作为神经疾病治疗点的潜力.

主要方法:

文献综述侧重于HBP,O-GlcNAc循环和神经元功能.
对将异常O-GlcNAcylation与神经疾病联系起来的研究进行分析.
关于O-GlcNAcylated蛋白调节和功能的信息综合.

主要成果:

失调的HBP代谢和O-GlcNAc循环与神经元疾病的诱导和进展有关.
虽然有证据将改变的O-GlcNAcylation与大脑病原发生联系起来,但因果关系仍在调查中.
特定的O-GlcNAcylated神经元蛋白质在维持正常大脑活动中起着至关重要的作用.

结论:

稳态调节O-GlcNAc循环对于大脑功能至关重要.
对O-GlcNAcylated神经元蛋白的进一步阐明可以确定神经系统疾病的新疗法标.
HBP/O-GlcNAcylation通路是理解和治疗大脑疾病的一个重要领域.

关键词:

这是一种O-GlcNAcylation.六胺生物合成途径神经退行症的神经退行症

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