在儿童中穿戴式检测强力发作:一项探索性队列研究
Renee Proost1, Jaiver Macea2, Lieven Lagae1
1Paediatric Neurology Department, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Epilepsia
|August 21, 2023
概括
一个可穿戴设备有效地检测了儿童的强力发作 (TS),在长时间的夜间事件中表现优于发作日记. 这项技术有助于开发自动发作检测算法.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 在儿童中诊断,特别是伦诺克斯-加斯托综合征,存在挑战.
- 准确的发作检测对于有效的治疗和治疗至关重要.
- 像日记这样的现有方法在准确性和一致性上有局限性.
研究的目的:
- 评估多模式可穿戴设备的性能,用于在儿童患者中线下检测强力发作 (TS).
- 专注于Lennox-Gastaut综合征和其他耐药性患者.
- 为了比较设备的准确性与传统的日记.
主要方法:
- 在视频EEG监测期间,一个可穿戴设备 (Plug 'n Patch系统) 记录了多个生物信号 (EEG,EMG,ECG,运动).
- 神经学家对生物信号进行了注释,并评估了发作检测性能.
- 关键指标包括灵敏度,积极预测值 (PPV),F1得分和错误报警率 (FAR).
主要成果:
- 该设备在13名儿科患者中检测到99个TS,包括那些患有伦诺克斯-加斯托综合征和智力障碍的人.
- 总体表现显示了41%的灵敏度和9%的PPV.
- 在长时间 (≥20秒) 的夜间中,性能显著改善,达到62%的灵敏度和82%的PPV,超过了日记.
结论:
- 对于患有和智力障碍的儿童来说,多式可穿戴设备是可行的.
- 使用该设备在线检测长时间的夜间增强性发作,超过了日记的准确性.
- 这项技术支持自动发作检测算法的开发.
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