一组尿路可以预测初级高血压中早期的损伤
Lirong Lin1, Jiangwen Ren2, Chunxuan Wang1
1Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital).
Journal of hypertension
|August 21, 2023
概括
一组新的尿可以预测高血压患者的新发蛋白尿症,帮助早期诊断和预防高血压性病. 这种生物标志物有助于识别高风险个体,以便及时进行干预.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 生物标志物发现发现
背景情况:
- 高血压 (HTN) 经常导致无症状的损伤,缺乏敏感的早期诊断标志物.
- 早期发现高血压损伤对于预防严重,不可逆转的损伤至关重要.
- 尿路被探索为预测高血压患者并发症的潜在生物标志物.
研究的目的:
- 调查尿作为生物标志物的实用性,用于高血压中早期预测损伤.
- 建立尿的切割值,以区分高血压损伤的风险水平.
- 评估尿在检测高血压患者新发蛋白尿的性能.
主要方法:
- 在健康人群中比较尿水平,在HTN患者中比较患有常态白蛋白尿症和在HTN患者中比较患有白蛋白尿症.
- 收集的基线数据包括人口统计,功能和高血压底部病变.
- 随访147名HTN患有正常白蛋白尿症的患者,以确定新发的蛋白尿症,并使用ROC分析计算尿切断值.
主要成果:
- 与健康个体相比,HTN患者的尿水平显著更高.
- 0.097的尿切断值有效预测了新发蛋白尿症 (AUC=0.925).
- 高风险患者 (尿>0.097) 呈现出较高的新发蛋白尿病率,升高的uACR,以及增加的Hcy,CysC和β2-MG水平.
结论:
- 一组特定的尿作为高血压新发蛋白尿的有价值预测剂.
- 这种尿路标记物有助于在高血压患者中诊断早期损伤.
- 这些发现支持使用尿用于早期预防和治疗高血压病的治疗策略.
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