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具有集成免疫检查点抑制的可电离性脂质纳米粒子用于mRNA CAR T细胞工程

Alex G Hamilton1, Kelsey L Swingle1, Ryann A Joseph1

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Advanced healthcare materials
|August 21, 2023
PubMed
概括

这项研究引入了一种新的脂质纳米粒子平台,用于暂时调节T细胞. 它同时提供基因表达和淘汰工具,通过减少自身免疫风险来增强癌症免疫治疗潜力.

关键词:
这是一个RNARNARNARNARNA.检查点接收器检查点接收器嵌合式抗原受体 嵌合式抗原受体免疫疗法 免疫疗法脂质纳米颗粒的使用方法它们是mRNARNA.siRNA 是一个RNA.

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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