在Mycobacterium tuberculosis中通过CD+T细胞和促炎细胞因子传播细菌
Kusuma Sai Davuluri1, Shoor Vir Singh2, D S Chauhan3
1Department of Microbiology & Molecular Biology, ICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra; Department Biotechnology, GLA University, Mathura, Uttar Pradesh, India.
The Indian journal of medical research
|August 21, 2023
概括
降低CD4+和CD8+T淋巴细胞数量与传播性结核病相关. 免疫细胞和细胞因子失调可能会推动Mycobacterium结核病的传播,这表明感染的潜在生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 结核病 (TB) 从局部到扩散形式的进展与CD4+和CD8+T淋巴细胞数量的下降有关.
- 免疫细胞表达的变化影响了扩散结核病的表现.
- 了解T细胞子集和细胞因子的作用对于结核病原性研究至关重要.
研究的目的:
- 研究T细胞子集 (CD4 +,CD8 +),促炎细胞因子和Mycobacterium结核病 (M.tb) 的传播之间的关系.
- 探索潜在的免疫因素作为传播结核病的生物标志物.
- 了解免疫反应如何促进结核病的传播.
主要方法:
- 15只海豚感染了M.tb H37Rv菌株.
- 将受感染的试验猪分成三组,每组5只.
- 对T细胞子集和促炎性细胞因子的血清和支气管支气管洗液 (BAL) 的分析.
主要成果:
- 结核菌菌 (M.tb) 可以逃避巨细胞由于亲炎性细胞因子失调.
- 由T细胞和细胞因子驱动的炎症可以促进M.tb扩散到其他器官.
- 高T细胞计数和刺激的细胞因子生产与炎症和结核病传播有关.
结论:
- 第4周CD4+T细胞和诱导炎症的细胞因子的过度表达可能导致8周脏中细菌增加.
- 这项试点研究表明,特定免疫反应与结核病传播之间存在联系.
- 需要进行更大规模的研究来证实这些发现及其临床影响.
相关概念视频
Pulmonary Tuberculosis II
262
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
262
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Pulmonary Tuberculosis I
266
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
266
Pulmonary Tuberculosis IV
162
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
162
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Pulmonary Tuberculosis III
363
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
363


