美国肌缩侧面硬化症的患病率,2018年
Paul Mehta1, Jaime Raymond1, Yuzi Zhang2
1Office of Innovation and Analytics, National ALS Registry, Agency for Toxic Substances and Disease Registry/Centers for Disease Control and Prevention, Atlanta, GA, USA and.
Amyotrophic lateral sclerosis & frontotemporal degeneration
|August 21, 2023
概括
据估计,2018年在美国有29,824人患有肌缩侧面硬化症 (ALS). 这项研究使用了捕获-重新捕获方法来改善国家ALS注册表的病例确定.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 神经学 神经学
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 准确的患病率估计对于资源分配和公共卫生规划至关重要.
- 国家ALS注册表旨在追踪美国的ALS病例.
研究的目的:
- 估计2018年美国普遍存在的肌缩侧面硬化症 (ALS) 病例数量.
- 评估国家ALS注册局对病例确诊的完整性.
- 提供美国人口中ALS的最新流行数据.
主要方法:
- 利用了来自国家行政数据库 (CMS,VHA,VBA) 和自愿提交的网络门户的数据.
- 采用日志线性捕获-重新捕获 (CRC) 建模来估计未确定病例.
- 分析人口统计数据以确定ALS影响的趋势.
主要成果:
- 国家ALS登记处确定了21,655例ALS病例 (流行率:6.6/100,000).
- 通过CRC方法估计总共有29824例流行ALS病例 (调整后的流行率:9.1/100,000).
- 登记处的确诊情况有所改善,2018年估计有27%的流行病例缺失 (2017年的44%下降).
结论:
- 美国的ALS患病率估计每年约为29,824例.
- 这些发现与之前基于CRC的估计结果一致,证实了持续的疾病负担.
- 人口趋势表明,ALS不成比例地影响50岁以上的白人男性.
相关概念视频
Parkinson's Disease: Overview
596
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
596
Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
Cross-bridge Cycle
117.7K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
117.7K
Prevalence and Incidence
627
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
627
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Alzheimer's Disease: Overview
518
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
518


