德国对降脂疗法的坚持和持续性进行了回顾性现实世界分析
Wolfgang Koenig1,2,3, Elke S Lorenz4,5, Lea Beier6
1Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. koenig@dhm.mhn.de.
概括
长期降脂疗法 (LLT) 在德国表现不佳. 在36个月后,他类药物持久率最低,这突显了心血管疾病风险减轻方面的重大挑战.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病是德国死亡的主要原因.
- 降脂疗法 (LLT) 通过降低低密度脂蛋白胆固醇来降低心血管风险.
- 不良的持续性和对LLT的坚持阻碍了有效的风险减轻.
研究的目的:
- 为了调查现实世界的持久性和对降脂疗法 (LLTs) 的坚持,直到开始后的36个月.
- 分析按年龄和性别分层的LLT持久性和坚持.
- 评估所覆盖日数 (PDC) 的比例,以此来衡量合规性.
主要方法:
- 使用匿名的德国处方数据进行回顾性队列研究 (2017年7月至2021年3月).
- 包括新处方他类药物,埃泽提米布或抗PCSK9单克隆抗体 (mAbs) 的患者.
- 使用覆盖日数比例 (PDC) 评估持久性和坚持性.
主要成果:
- 在所有LLT子组中,持久性逐渐下降;女性的持久性比男性低.
- 36个月的PDC平均值为他类药物的0.84,以西西米布的0.92和抗PCSK9mAbs的0.93.
- 在36个月后,他类药物的持续率为20.6%,埃泽胺为22.3%,抗PCSK9 mAbs的持续率为50.9%.
结论:
- 对所有分析的降脂疗法 (LLT) 观察到高不持续率.
- 在研究的LLTs中,他类药物表现出最低的持续率.
- 改善LLT持久性对于有效的心血管疾病风险管理至关重要.
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