神经病患者的自身免疫过程比目前怀疑的更为常见
Angelika Goertzen1, Abdul Kareem Altawashi1, Julian Rieck2
1AMEOS Klinikum St. Clemens Oberhausen, Wilhelmstrasse 34, D-46145, Oberhausen, Germany.
Journal of neurology
|August 21, 2023
概括
自身免疫性脑炎比以前认为的更常见,每年有超过125名患者可能在脑脊液 (CSF) 中具有自身反应性抗体. 提高意识可以帮助神经科医生识别这些患者及时进行免疫调节疗法.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性脑细胞被认为是罕见的,但它们的实际发病率尚不清楚.
- 低发病率和诊断挑战可能会限制神经学家在患有不清楚症状的患者中识别自身免疫性脑炎.
研究的目的:
- 估计神经系统住院患者自身免疫性疾病的患病率.
- 确定传统神经病学部门每100名住院患者中预期的自身免疫性疾病患者人数.
主要方法:
- 在2年的时间里,分析了来自非中风患者的460个脑脊液 (CSF) 样本.
- 对187个脑脊液样本进行免疫细胞化学分析,以检测自身反应性抗体.
- 根据检测到的抗体患病率计算预期发病率.
主要成果:
- 在55% (102/187) 的分析的脊髓样本中检测到自身反应性抗体.
- 据估计,在传统的神经病学部门每年约有125名患者可能具有自身反应性CSF抗体.
- 这比目前预期的发病率高出35倍.
结论:
- 自免疫性脑炎的发病率可能被严重低估.
- 提高对更高患病率的认识可以改善患者的鉴定和免疫调节疗法治疗.
- 针对海马CA2区域的抗体可能会导致自身免疫性脑炎的神经精神症状.
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