相关实验视频

Updated: Jul 18, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.5K

揭开药物诱导胆固醇性肝损伤的潜在机制:使用机器学习技术识别人类体外数据集中的关键基因

Jian Jiang1, Jonas van Ertvelde2, Gökhan Ertaylan3

  • 1Entity of In Vitro Toxicology and Dermato‑Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. jian.jiang@vub.be.

Archives of toxicology
|August 21, 2023
PubMed
概括

这项研究使用机器学习识别了13个关键基因,用于预测药物诱导的肝内胆固醇症 (DIC). 这种方法通过提高预测人类肝脏毒性的准确性来增强早期药物开发.

关键词:
药物诱导的胆固醇形成.功能选择 功能选择机器学习 机器学习监督的分类是监督的分类.包装包装的特征选择选项

更多相关视频

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.2K
Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.3K

相关概念视频

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
61