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相关概念视频

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
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相关实验视频

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Flow Cytometric Analysis of Extracellular Vesicles from Cell-conditioned Media
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细胞外囊泡和心脏衰老

Fernando A C Seara1,2, Leonardo Maciel1,3, Tais Hanae Kasai-Brunswick1,4

  • 1Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Advances in experimental medicine and biology
|August 21, 2023
PubMed
概括

人口老龄化面临着健康挑战,特别是心血管疾病. 衰老细胞释放细胞外囊泡 (EVs),有助于心脏衰老,但干细胞EVs可能提供抗衰老疗法.

关键词:
衰老的衰老 衰老的衰老心脏衰老的心脏衰老细胞外囊泡中的细胞外囊泡.衰老是一种衰老.

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科学领域:

  • 心血管科学 心血管科学
  • 老年学是一门学科.
  • 细胞生物学 细胞生物学

背景情况:

  • 全球人口老龄化带来了重大的健康和社会经济挑战.
  • 心血管疾病是老年人死亡的主要原因.
  • 心脏衰老细胞的积累及其分泌的因素有助于与年龄有关的心血管衰退.

研究的目的:

  • 研究衰老细胞及其分泌的细胞外囊泡 (EVs) 在心血管衰老中的作用.
  • 探索电动汽车作为衰老相关疾病的生物标志物的潜力.
  • 检查干细胞和原始细胞衍生的EVs对抗衰老策略的治疗潜力.

主要方法:

  • 衰老细胞释放的与衰老相关的分泌表型 (SASP) 化合物的分析.
  • 由衰老细胞分泌的细胞外囊泡 (EVs) 的表征.
  • 研究受体细胞对EV的吸收及其对细胞功能和细胞外基质的影响.
  • 探索从干细胞和祖细胞中获得的EV,以寻找潜在的再生效应.

主要成果:

  • 衰老细胞释放含有SASP因子和受损分子的EV.
  • 这些EV可以被邻近的细胞内化,造成损伤并促进纤维化和血管化.
  • 与衰老相关的EVs的分子特征是可变的,这表明生物标志物的潜力.
  • 来自干细胞和祖细胞的EVs可能具有再生性质.

结论:

  • 衰老细胞衍生的EV在与年龄有关的心血管功能障碍中发挥着关键作用.
  • 电动汽车是新型衰老生物标志物的潜在来源.
  • 来自干细胞和祖细胞的EV对未来的抗衰老疗法具有前途.