用生物治疗的克罗恩病患者肠硬度的连续变化:使用超声波剪切波弹性图形的试点研究
Hiroshi Matsumoto1, Jiro Hata2, Shogen Yo1
1Division of Internal Medicine, Department of Gastroenterology, Kawasaki Medical School, Matsushima, Kurashiki, Okayama, Japan.
概括
剪切波弹性图可以评估克罗恩氏病狭窄硬度. 与infliximab或bio-switch不同的是,ustekinumab治疗显著降低了克罗恩病患者的硬度.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 类风湿病学 类风湿病学
背景情况:
- 肠道狭窄是克罗恩病的一个严重并发症.
- 剪波弹性图 (SWE) 是一种非侵入性的超声波技术,用于测量组织硬度.
- 评估狭窄硬度及其对生物制剂的反应对于克罗恩病的管理至关重要.
研究的目的:
- 为了评估使用SWE的克罗恩病患者的肠狭窄硬度.
- 评估治疗生物药物后硬度的变化,包括infliximab,ustekinumab和生物开关疗法.
主要方法:
- 21名克罗恩病患者的肠道收缩被纳入.
- 患者被分为infliximab-naïve, ustekinumab-naïve和生物开关组.
- 肠壁厚度和SWE在生物治疗前和1年后进行测量.
主要成果:
- 在所有治疗组中,肠壁厚度显著改善.
- 剪波速度指数仅在乌斯特基努马布组显著下降 (P = .028).
- 在infliximab或生物开关组中没有观察到硬度的显著下降.
结论:
- 在接受生物治疗的克罗恩病患者中,SWE可能是评估肠硬度的有用工具.
- 需要进一步的前性随机研究来验证这些发现,并评估生物治疗后阻塞的发展.
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