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Updated: Jul 18, 2025

RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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除了PPR-RNA识别代码之外:许多方面对RNA编辑因子PPR56的多重定位特性具有重要意义

Yingying Yang1, Kira Ritzenhofen1, Jessica Otrzonsek1

  • 1IZMB-Institut für Zelluläre und Molekulare Botanik, Abteilung Molekulare Evolution, Universität Bonn, Bonn, Germany.

PLoS genetics
|August 21, 2023
PubMed
概括

的Physcomitrium patens PPR56蛋白有效编辑大肠杆菌中的线粒体RNA,揭示了100多个目标之外的编辑. 修改提高了编辑效率,为RNA编辑机制提供了洞察力.

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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