Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

5.0K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
5.0K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

1.3K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
1.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Duodenal Mucosa Plays a Key Role in Metabolic Regulation: Emerging Physiology and New Opportunities for Cell-Directed and Barrier-Related Interventions for the Treatment of Diabetes and Obesity.

Diabetes, obesity & metabolism·2026
Same author

Publisher Correction: GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.

Nature·2026
Same author

The Glucagonotropic Effect of GIP Is Negated During Insulin-Induced Hypoglycemia in Type 1 Diabetes: A Randomized, Placebo-Controlled, Crossover Study.

Diabetes·2026
Same author

GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.

Nature·2026
Same author

Clinical Potential of GIP in Type 2 Diabetes and Obesity.

Diabetes care·2026
Same author

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat.

EMBO reports·2025

相关实验视频

Updated: Jul 18, 2025

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.0K

GPCR的淫荡性重塑了岛屿生理学.

Frans Schuit1, Jonathan E Campbell2

  • 1Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Diabetes
|August 21, 2023
PubMed
概括
此摘要是机器生成的。

葡萄糖和类似葡萄糖的1 (GLP-1) 具有惊人的相似性,在相同的受体上起作用. 这一发现重新塑造了我们对这些激素如何调节新陈代谢的理解,挑战了长期以来持有的相反观点.

更多相关视频

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.2K
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.5K

相关实验视频

Last Updated: Jul 18, 2025

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.0K
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.2K
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.5K

科学领域:

  • 代谢调节 代谢调节 代谢调节
  • 内分泌学 在内分泌学.
  • 分子生物学分子生物学

背景情况:

  • 葡萄糖和类似葡萄糖的1 (GLP-1) 是由相同的前激素衍生出来的.
  • 传统上,葡萄糖被视为具有代谢作用的禁食激素,而GLP-1则被视为具有合成代谢作用的食后激素.
  • 尽管它们有不同的作用,但它们的作用和受体结合的相似性已被发现.

研究的目的:

  • 重新检查一项关于葡萄糖和GLP-1的基础研究.
  • 要突出葡萄糖和GLP-1的共同特征和受体相互作用.
  • 讨论这些发现对当前代谢调节研究的影响.

主要方法:

  • "糖尿病"杂志上发表的一项经典研究的文献综述和再分析.
  • 对葡萄糖和GLP-1的生理作用进行比较分析.
  • 讨论从初步观察中得出的研究进展.

主要成果:

  • 葡萄糖和GLP-1表现出比以前估计的更多的共同点.
  • 这两种可以通过相同的受体起作用.
  • 这种共享的机制挑战了它们代谢作用的二分法.

结论:

  • 关于葡萄糖和GLP-1的对立代谢作用的传统观点是一种过度简单化.
  • 共享的受体活性表明在代谢控制中具有更完整的作用.
  • 几十年的研究受到了这一观察的影响,导致对前葡萄糖激素功能的理解得到了修订.