新生儿中的全基细胞疗法应用:系统性审查
Abdul Razak1,2,3, Donna Lei1, Courtney A McDonald3,4
1Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
Stem cells translational medicine
|August 21, 2023
概括
全基细胞疗法在新生儿中表现有前途,主要使用介质细胞 stromal 细胞 (MSC). 虽然通常是安全的,但需要对其他细胞类型和疗效进行进一步的研究,特别是在移植与宿主疾病 (GVHD) 方面.
科学领域:
- 新生儿医学 新生儿医学
- 再生医学是一种再生医学.
- 细胞疗法细胞疗法
背景情况:
- 新生儿细胞疗法正在扩大,但对全原细胞疗法的证据仍然有限.
- 本系统性审查涉及新生儿全基细胞治疗的安全性,可行性和疗效.
研究的目的:
- 系统地审查和总结有关终期和早产新生儿全源细胞疗法的现有证据.
- 确定各种细胞类型和新生儿疾病的安全问题,可行性方面和疗效数据.
主要方法:
- 在主要数据库 (Cochrane,Embase,Ovid Medline) 和临床试验注册表中进行全面的文献搜索.
- 独立的文章选择,数据提取,以及两位作者对偏见风险的评估.
- 包括12项已发表的研究 (153名婴儿) 和21项正在进行的研究的数据.
主要成果:
- 来自带血 (UCB) 的介质细胞 (MSC) 是主要使用的细胞类型.
- 主要应用包括支气管肺功能障碍 (BPD),克拉贝病和缺氧缺血性脑病变.
- 大多数研究报告没有严重不良事件 (SAE);然而,在少数情况下报告了移植对宿主疾病 (GVHD) 和过渡性心肺呼吸系统损害.
结论:
- 全基细胞疗法,特别是MSCs,在新生儿中似乎是安全的和可行的.
- 对非MSC细胞类型需要进一步的安全数据,GVHD的风险需要彻底调查.
- 目前,在所有研究的细胞类型和新生儿疾病中缺乏可靠的疗效数据.
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