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Updated: Jul 18, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

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通过PERK-eIF2α-ATF4-CREB3L1通路,C5a-C5aR1诱导了内等质网膜应激,以加速血管化

Aiting Liu1, Zhenwei Chen2, Xiaoxue Li1

  • 1Department of Cardiology, Joint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic Diseases, The Eighth Affiliated Hospital of Sun Yat-sen University, Shennan Middle Rd, Shenzhen, 518000, China.

Cardiovascular research
|August 21, 2023
PubMed
概括

高C5a水平通过激活C5a受体1 (C5aR1) 来增加血管化 (VC) 风险. 这触发了内等质网膜应激和PERK-eIF2α-ATF4-CREB3L1通路,促进了VSMC骨质性转基因分化. 准C5或C5aR1可以治疗VC.

关键词:
在C5a-C5aR1中.这就是CREB3L1的意思.细胞内膜网膜应激压力通过PERK-eIF2α-ATF4路径.血管化是因为血管化.

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