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蒙特卡洛计算了临床质子束中的电离室校正因子 - - 从已发表的数据中得出不确定性

Kilian-Simon Baumann¹, Carles Gomà², Jörg Wulff³

¹University Medical Center Giessen-Marburg, Department of Radiotherapy and Radiooncology, Marburg, Germany; University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen, Germany; Marburg Ion-Beam Therapy Center, Marburg, Germany.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|August 21, 2023

概括

对质子束剂量计的新蒙特卡洛计算提供了更新的电离室系数 (f_Q) 和光束质量校正系数 (k_Q). 这些结果为临床质子疗法提供了更好的准确性,与当前国际原子能机构指南相比,减少了不确定性.

科学领域:

医学物理医学物理
辐射剂量计辐射剂量计
蒙特卡罗模拟的蒙特卡罗模拟

背景情况:

国际原子能机构 (IAEA) TRS-398实践准则 (CoP) 为临床质子束剂量计提供了指导方针.
精确的电离室系数 (f_Q) 和光束质量校正系数 (k_Q) 对于质子疗法中可靠的剂量校准至关重要.
现有的IAEA TRS-398值可能需要根据先进的模拟技术进行更新.

研究的目的:

使用蒙特卡洛方法计算临床质子束的更新的全球电离室系数 (f_Q) 和光束质量校正系数 (k_Q).
估计与这些蒙特卡洛衍生因素相关的不确定性.
为了将新因素与现有和即将到来的国际原子能机构TRS-398 CoP值进行比较.

主要方法:

平均蒙特卡洛计算了来自文献的f_Q因子,用于涵盖六个平面平行和三个圆柱形电离室的195个数据集.
使用PENH,FLUKA和GEANT4蒙特卡洛代码进行了计算,用于60MeV至250MeV的质子束能量.
从平均f_Q因子中导出k_Q因子,并分析了与国际原子能机构TRS-398值的一致性和差异.

主要成果:

平均蒙特卡洛计算的f_Q因子在整个研究的能量范围内保持在0.6%的范围内.
不同的蒙特卡洛代码之间的差异从低能量的1%到高能量的2%不等.
衍生的k_Q因子显示出与2000年IAEA TRS-398 CoP值的偏差高达2.4%,但与即将到来的版本一致在1%内.
蒙特卡洛计算的k_Q因子的估计不确定性比IAEA TRS-398的不确定性小0.5%-1%.

结论:

蒙特卡洛模拟为质子剂量计提供可靠的f_Q和k_Q因子,精度提高,不确定性降低.
更新的因素对于完善剂量测量方案和提高质子疗法的精度至关重要.
该研究强调了先进的模拟技术在更新和改进既定剂量计代码方面的价值.

关键词:

波束质量校正因子的校正因子国际原子能机构的TRS-398 CoP.蒙特卡罗的蒙特卡罗是一个非常好的城市.质子剂量计是质子剂量计.质子疗法是一种质子疗法.

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