卵巢皮层的卵泡密度的参考标准从出生到性成熟
Jasmin Hassan1, Katri Knuus2, Atte Lahtinen3
1Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden; Department of Gynaecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
Reproductive biomedicine online
|August 21, 2023
概括
卵巢皮层卵泡密度的年龄正常化参考值足以评估生育保护组织质量. Z-分数有效估计治疗效果,并有助于识别年轻患者的卵巢储量减少.
科学领域:
- 生殖生物学 生殖生物学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 在接受化疗等治疗的年轻患者中,保护生育能力至关重要.
- 准确评估卵巢组织质量对于成功保持生育能力至关重要.
- 对于卵巢卵泡密度的确定的参考值是需要进行质量控制的.
研究的目的:
- 评估人类卵巢皮层卵泡密度的年龄规范化参考值在组织质量控制中的适度,以保护生育能力.
- 评估Z-score在估计与治疗相关的对卵巢卵泡密度影响的有用性.
- 确定年轻患者卵巢储备减少的潜在指标.
主要方法:
- 用卵巢卵泡计数的定量数据来确定皮质密度的年龄正常化参考值.
- 对126名接受癌症治疗,血液病治疗或被诊断患有特纳综合征的女孩 (1-24岁) 的队列,计算了Z分数.
- 进行了统计分析,以比较不同患者组之间的Z分数,并评估与治疗暴露和年龄的相关性.
主要成果:
- 在未接受治疗的患者和接受基化疗或不接受基化疗的患者之间,没有观察到Z-分数的显著差异.
- Z-分数与累积细胞静止剂暴露无关,但与较年长的治疗患者 (11-19岁) 相比,在非常年轻的治疗患者 (0-2岁) 中显著较低.
- 图纳综合征患者的Z分数明显低于未接受治疗的患者,Z分数截止值为-1.7,有效地识别了卵巢储备减少. 年轻的患者和患有非恶性血液病的患者表现出卵巢储备减少的迹象.
结论:
- 从年龄规范化的参考值得出的Z-score对于估计卵巢卵泡密度的遗传和治疗相关影响在生育保存样本中是有价值的.
- 使用Z分数来了解冷保存的组织质量可以提高患者的咨询.
- 需要进一步的研究来阐明细胞静止剂对卵巢卵泡密度的特定影响.
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