晚期癌症和预期寿命有限的老年人药物优化:一项前性观察性研究
Edwin J Brokaar1, Loes E Visser2, Frederiek van den Bos3
1Department of Pharmacy, Haga Teaching Hospital, PO Box 40551, 2504 LN The Hague, the Netherlands.
Journal of geriatric oncology
|August 21, 2023
概括
患有癌症的老年人经常面临与药物相关的问题 (DRPs) 和可能不合适的药物 (PIMs). 多学科的方法显著减少了这些问题,并提高了患者的满意度.
科学领域:
- 老年瘤学 老年瘤学
- 临床药房 临床药房
- 药物经济学 药物经济学
背景情况:
- 多药在患有癌症的老年人中很普遍,导致与药物相关的问题 (DRPs) 和潜在的不合适药物 (PIMs).
- 患有晚期癌症和预期寿命有限的老年人特别容易受到与药物相关的问题.
- 优化药物治疗方案对于改善这一群体的结果和生活质量至关重要.
研究的目的:
- 评估药物优化护理途径在治疗晚期癌症的老年人中减少DRP和PIM的有效性.
- 评估瘤学家对药物相关建议的遵守情况.
- 为了确定患者对药物优化干预的满意度.
主要方法:
- 对65岁以上的多药患者和预期寿命小于24个月的患者进行了一项药物评估.
- 在一个多学科团队 (药剂师,瘤学家,老年医生) 中讨论了建议.
- 通过干预后四周的问卷评估患者的满意度.
主要成果:
- 包括120名患者 (平均年龄75岁);平均每名患者服用12种药物.
- 每位确诊患者的中位数为6.0个DRP和3.0个PIM.
- 多学科团队接受了78%的建议;瘤学家执行了54%.
结论:
- 在患有晚期癌症的老年人中,DRP和PIM非常普遍.
- 多学科药物优化干预可以有效地减少DRP和PIM.
- 患者表示对药物优化干预措施的满意度很高.
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