通过使用虚拟莫里斯水迷宫 (vMWM) 和NIH工具箱任务,研究年龄和以前的军事服务对流体和结晶认知功能的影响
Adina Mollusky1, Nadjalisse Reynolds-Lallement1, Dylan Lee1
1Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, United States.
Archives of gerontology and geriatrics
|August 21, 2023
概括
与非退伍军人相比,老年男性退伍军人在空间学习和记忆方面表现出显著的认知下降. 虚拟莫里斯水迷宫任务对军事服务更为敏感.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知心理学 认知心理学
背景情况:
- 目前的老龄化研究通常集中在使用一般化测试的退伍军人身上.
- 对退伍军人年龄相关认知变化的研究通常检查健康或神经系统疾病.
研究的目的:
- 为了研究健康个体的正常年龄相关的认知变化,比较年轻人和老年人.
- 通过使用新任务来检查服兵役对老年男性退伍军人的认知功能的影响.
主要方法:
- 利用虚拟的莫里斯水迷宫 (vMWM) 任务来评估年轻人和老年人的空间学习,认知灵活性和工作记忆.
- 退伍军人和非退伍军人之间的比较认知表现,包括老年男性,年轻女性和老年女性.
- 与NIH工具箱 (NIH-TB) 认知电池和韦克斯勒记忆量表 (WMS) 测试相比,验证了vMWM任务.
主要成果:
- 在vMWM和NIH-TB流体认知任务中观察到与年龄相关的显著缺陷.
- 在年长的男性中,vMWM任务显示出比NIH工具箱任务对以前的军事服务的敏感性更大.
- 与年龄相匹配的非退伍军人和年轻人相比,老年男性退伍军人在空间学习,认知灵活性和vMWM任务上的工作记忆方面表现出显著的缺陷.
结论:
- vMWM任务对研究认知衰老有价值,并显示出对衰老干预措施跨物种翻译的希望.
- 之前的军事服务可能会作为一个重要的,以前未被识别的变量,影响正常的与年龄相关的认知衰退,特别是在老年男性中.
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