海洋抗生素耐药性基因及其表达的全球地图
Nuohan Xu1, Danyan Qiu1, Zhenyan Zhang1
1College of Environment, Zhejiang University of Technology, Hangzhou 310032, China.
Water research
|August 21, 2023
概括
海洋细菌携带抗生素耐药性基因 (ARG),这些基因因因海洋深度和度而异. 大多数已识别的ARG都表达,高风险基因表达增加,可能受到人类活动的影响.
科学领域:
- 海洋微生物学 海洋微生物学
- 环境基因组学 环境基因组学
- 抗生素耐药性 抗生素耐药性
背景情况:
- 海洋是抗生素耐药细菌和抗生素耐药基因 (ARG) 的重要储存库.
- 对于海洋环境中ARG特征和表达的理解有限,特别是对环境因素的反应.
研究的目的:
- 研究海洋生态系统中ARG的分布,宿主和表达.
- 为了确定核心海洋抗体及其遗传宿主范围.
- 评估环境因素和人类活动对ARG表达的影响.
主要方法:
- 分析了347个海洋元基因组和182个元转录基因组.
- 确定ARG的多样性,丰度和宿主协会.
- 使用机器学习量化ARG表达水平并预测未来的变化.
主要成果:
- 根据度和海洋深度,ARG的多样性和丰富性有很大变化.
- 核心海洋抗体主要对糖和多种药物产生抗性,宿主主要局限于核心海洋微生物群.
- 65%的已识别的海洋ARG被表达,超过90%的高风险ARG显示出更高的表达可能性.
- 人类活动可能通过营养度和海洋温度的变化影响ARG表达.
- 机器学习预测,到2100年,超过97%的海洋ARG将改变表达,高风险的ARG将转移到较低的度和受人类影响的地区.
结论:
- 已经确定了一个核心海洋抗体,量化了ARG表达,为未来的控制策略提供了基线.
- 了解ARG在电阻和元素循环中的双重作用对于评估生态系统和人类健康影响至关重要.
- 由于全球变化,ARG表达的未来变化需要全面的监测和风险评估.
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