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用一线单剂多克索鲁比治疗的子宫乳腺髓瘤患者的伪进展

Lucy-Rose Howroyd¹, Isabel Cornell¹, Charlotte Benson¹

¹Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

European journal of cancer (Oxford, England : 1990)

|August 21, 2023

概括

伪进展,瘤大小的初始增加,随后收缩,发生在19%的用多克索鲁比治疗的子宫乳腺肌肉瘤患者中. 意识对于持续治疗稳定的患者至关重要.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
肉瘤研究研究肉瘤研究

背景情况:

doxorubicin 是用于软组织肉瘤的标准一线化疗.
伪进展在子宫乳腺髓瘤 (LMS) 之前没有被描述.

研究的目的:

为了确定患有转移性或不可手术的子宫LMS的患者接受一线多克索鲁比的伪进展的发生率.
评估Choi标准在识别伪进展方面的有用性.

主要方法:

对52名转移性/不可手术的LMS患者进行了回顾性审查,这些患者接受了多克索鲁比治疗.
使用固体瘤响应评估标准 (RECIST) v1.1和Choi标准进行计算机断层扫描的分析.
伪进展定义为最初的瘤生长,其次是大小的减少.

主要成果:

在19% (10/52) 的患者中观察到伪进展.
伪进展与 doxorubicin 失败的时间无关.
选择标准确定了30%的伪进步者是响应者,表明了潜在的错误分类.

结论:

伪进展是用多克索鲁比治疗子宫LMS的一个显着现象.
放射科医生和瘤科医生必须识别伪进展,以避免过早停止治疗.
持续的多克索鲁比治疗可能有利于明显初始瘤生长但症状稳定的患者.

关键词:

疾病进展疾病进展.德克索鲁比辛是一种多克索鲁比辛.莱奥米奥萨科马斯 (Leiomyosarcomas) 是一个伪进步是一种伪进步.放射性反应的反应这种类型的瘤是sarcomas.系统性疗法是一种全身疗法.子宫瘤是什么子宫瘤

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