血管健康和儿童时期血压进展的双变关系
Christoph Hauser1, Giulia Lona1, Sabrina Köchli1
1Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel-Stadt, Switzerland.
Atherosclerosis
|August 21, 2023
概括
儿童血压 (BP) 的进展与视网膜微血管变化和动脉硬有关. 在儿童中早期发现这些血管功能障碍可以为心血管疾病预防策略提供信息.
科学领域:
- 儿科心脏病学 儿科心脏病学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- 高血压是成人心血管疾病 (CVD) 的主要危险因素.
- 亚临床血管损伤,包括高血压 (BP),可以在儿童时期表现出来.
- 早期识别儿童的血管变化对于长期的心血管健康至关重要.
研究的目的:
- 调查视网膜微血管直径和大动脉脉冲波速度 (PWV) 与儿童血压进展之间的关联.
- 为了确定基线血管参数是否预测未来的血压变化.
- 评估基线血压是否预测未来的血管变化.
主要方法:
- 对1171名年龄在6-8岁的儿童进行前性队列研究.
- 在基线标准化测量血压,体重指数,视网膜血管直径和PWV.
- 在4年后,对749名儿童进行这些参数的后续评估.
主要成果:
- 开始时较窄的视网膜中心动脉直径 (CRAE) 和较高的PWV与4年后的缩血压增加有关.
- 基线时心血压升高与随访时更窄的CRAE和更高的PWV有关.
- 视网膜动脉直径和PWV独立预测了血压的进展,表明了双向关系.
结论:
- 视网膜动脉直径和PWV是儿童BP进展的独立预测指标.
- 儿童高血压与微型和宏观血管障碍的发展有关.
- 儿童时期是实施针对高血压和未来心血管疾病的初级预防策略的关键窗口.
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