高系统性炎症反应指数水平与下肢深静脉血栓形成的风险增加有关:一项大型回顾性研究
Hailong Liu1, Xi Chen1, Zhicong Wang1,2
1Department of Orthopedics, People's Hospital of Deyang City, Deyang, China.
Annals of medicine
|August 21, 2023
概括
高系统炎症反应指数 (SIRI) 与住院患者的下肢深静脉血栓形成 (LEDVT) 风险增加有关. 这种随时可用的生物标志物为LEDVT风险评估提供了进一步的临床研究的理由.
科学领域:
- 医学研究 医学研究
- 临床生物标志物 临床生物标志物
- 血管医学 血管医学
背景情况:
- 炎症越来越多地与静脉血栓栓塞 (VTE) 有关.
- 系统性炎症反应指数 (SIRI) 是一种新的炎症生物标志物.
- 在SIRI和下肢深静脉血栓症 (LEDVT) 之间的关联仍然未被探索.
研究的目的:
- 调查SIRI和LEDVT风险之间的关联.
- 在10年期间 (2012-2022) 分析来自大量患者样本的数据.
主要方法:
- 对12643名接受下肢压缩超声波 (CUS) 的住院患者的回顾性分析.
- 采用了多变量逻辑回归,灵敏度,受限立方线和子组分析.
- 研究了SIRI水平与LEDVT发生之间的关联.
主要成果:
- 在较高的SIRI水平和LEDVT风险增加之间发现了显著的关联 (OR=1.098,p<0.001).
- 与最低四分位数相比,SIRI最高四分位数的患者患LEDVT的风险增加了2563倍.
- 观察到一种非线性关系,转折点为SIRI=4.17;在这个点以下,风险显著增加.
结论:
- 升高的SIRI与住院患者LEDVT风险更高显著相关.
- 在临床实践中,SIRI是一种易于获得的生物标志物.
- 需要进一步探索SIRI在管理LEDVT风险方面的临床实用性.
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