相关实验视频
Updated: Jul 18, 2025

07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
8.3K
慢性自发性疹患者中较高的室内灰尘虫特异性IgE水平可能意味着较高的基细胞活性
Gaopeng Liang1, Jie Zhou2, Lanlan Jiang2
1Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China, 876496115@qq.com.
International archives of allergy and immunology
|August 21, 2023
概括
慢性自发性疹 (CSU) 患者具有较高的室内灰尘虫特异性IgE (HDM-sIgE) 水平,表现出基细胞的活性增加. 这表明在CSU病原发生过程中,过敏敏感化和基细胞激活之间存在联系.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 皮肤病学 皮肤病学
背景情况:
- 过敏原特异性IgE (sIgE) 敏感化存在于慢性自发性疹 (CSU) 患者的很大一部分患者中.
- 基细胞在CSU的基本机制中发挥作用.
研究的目的:
- 调查CSU患者的过敏敏感化和基细胞反应之间的关联.
- 探索将HDM-sIgE水平与CSU中的基细胞激活联系起来的潜在机制.
主要方法:
- 从76名CSU患者和9名健康对照人群中分离了周围血液白细胞.
- 基基 CD63 和 FcεRIα 表达通过流动细胞计与室内灰尘虫 (HDM) -sIgE水平相关分析.
- 在用HDM过敏原或其他刺激刺激后,评估了基细胞的活性和SHIP-1表达.
主要成果:
- 与正常水平和健康对照组相比,高HDM-sIgE (≥3.5kU/L) 的CSU患者表现出基因细胞CD63和FcεRIα表达的升高.
- 来自HDM-sIgE阳性CSU患者的基细胞对皮肤虫类酸酶1 (Derp1) 刺激的反应性增加.
- 联合Derp1和Derp1-sIgE刺激诱导了HDM-sIgE阳性CSU患者显著更高的SHIP-1mRNA表达.
结论:
- 在CSU患者中,HDM-sIgE水平升高与外周血液基细胞的CD63和FcεRIα表达增加相关.
- 这些患者的外周血液基因细胞对HDM过敏原暴露的反应增加.
- 较高的HDM-sIgE水平可能表明基细胞活性增加,有助于CSU的发病.
相关概念视频
Allergic Reactions
27.8K
Overview
27.8K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
342
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
342
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management
443
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
443
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Hypersensitivities
737
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
737

