[与MEN1相关的双胞胎胰腺神经内分泌新生体的指示和手术程序]
Jerena Manoharan1, Max Albers1, Detlef K Bartsch1
1Klinik für Visceral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Gießen und Marburg - Standort Marburg, Marburg, Deutschland.
Zentralblatt fur Chirurgie
|August 21, 2023
概括
在多重内分泌瘤1型中,十二胰腺神经内分泌瘤 (dpNEN) 的最佳手术治疗包括切除大于2厘米的瘤或疑似恶性瘤. 目标是控制症状,预防转移,并保持胰腺功能和生活质量.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 在多重内分泌瘤1型的背景下,双胞胎胰腺神经内分泌瘤 (dpNEN) 提出了复杂的治疗挑战.
- 由于dpNEN的罕见性限制了前性随机研究,因此需要依赖后性数据来制定治疗指南.
研究的目的:
- 概述目前关于dpNEN在1型多重内分泌瘤患者手术治疗的建议.
- 确定手术干预的标准,并讨论适当的手术技术.
主要方法:
- 回顾回顾案例系列和关于dpNEN管理的现有文献.
- 分析手术指示,包括瘤大小,功能状态和恶性瘤的怀疑.
- 评估外科手术程序,如核切除和胰腺切除.
主要成果:
- 对于非功能性dpNEN>2厘米,功能性活跃dpNEN以及疑似恶性瘤的患者,注明进行手术治疗.
- 手术选择包括核切除或正式的胰腺切除,潜在的淋巴切除术.
- 治疗目标侧重于缓解症状和预防转移性疾病的进展.
结论:
- 对于dpNEN的外科干预旨在平衡瘤控制与胰腺功能和患者生活质量的维护.
- 对于年轻患者来说,需要强调护理膜节约切除,以保持长期的健康.
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