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在老鼠中 Ferrum phosphoricum 的急性和次急性口服毒性评估

Mahima Sharma¹, Sangita Behera¹, Raj Kumar Regar¹

¹Department of Pharmacology, Drug Standardisation, Dr D P Rastogi Central Research Institute (H), Noida, Uttar Pradesh, India.

Homeopathy : the journal of the Faculty of Homeopathy

|August 21, 2023

概括

在6c,30c和200c强度的顺势疗法Ferrum phosphoricum (FP) 没有在Wistar大鼠中表现出急性或亚急性口服毒性. 这项研究证实了FP在长期使用中的安全性.

科学领域:

顺势疗法顺势疗法顺势疗法
毒理学毒理学毒理学
药理学药理学是指药理学的学科.

背景情况:

传统上使用的是酸铁 (FP),但缺乏科学安全数据.
调查顺势疗法FP的安全性对于其临床应用至关重要.

研究的目的:

在实验大鼠中评估顺势治疗法 (Ferrum phosphoricum,FP) 的急性和亚急性口服毒性.
为了建立FP6c,30c和200c功率的安全概况.

主要方法:

使用经济合作与发展组织 (OECD) 准则423的急性口服毒性研究.
经合组织指导方针407的下急性口服毒性研究,持续28天.
综合性监测包括死亡率,临床症状,体重,血液学,生物化学和组织病理学.

主要成果:

在急性研究中,FP的中位致命剂量 (LD50) 确定为>2,000μL/kg.
在为期28天的亚急性毒性研究中,没有观察到死亡率或不良临床症状.
血液学,生化学和组织病理学分析没有显示与治疗相关的异常.

结论:

在6c,30c和200c强度的顺势疗法Ferrum phosphoricum (FP) 在Wistar老鼠口服时是安全的.
该研究提供了科学证据,支持FP长期使用的安全性.

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