作为糖尿病病的协同潜在生物标志物,V-ATPase C 1 亚单元和 IKBIP 是糖尿病病的协同潜在生物标志物
Siska Darmayanti1, Ronny Lesmana2, Anna Meiliana1
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; Prodia Clinical Laboratory, Jakarta, Indonesia.
Diabetes research and clinical practice
|August 21, 2023
概括
尿中的低分子量 (LMW) 蛋白质,特别是V-ATPase亚单元C 1和IKBIP,显示出可能成为2型糖尿病患者糖尿病病 (DN) 的早期生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 蛋白质组学是指蛋白质组学.
- 生物标志物发现发现
背景情况:
- 糖尿病病 (DN) 是2型糖尿病 (T2DM) 的一个主要并发症.
- 尿中低分子量 (LMW) 蛋白质可能表明球毛细血管壁损伤.
- LMW 蛋白质可以作为 DN 的预测标记.
研究的目的:
- 确定和评估尿液LMW蛋白作为T2DM患者DN的潜在生物标志物.
- 研究特定LMW蛋白与DN进展的关联.
主要方法:
- 使用液体染色学-并联质谱法进行尿液蛋白质谱分析.
- 对T2DM患者 (n=94) 和对照组 (n=32) 的比较.
- 识别和量化非向的LMW蛋白质.
主要成果:
- 确定了73种LMW蛋白;32种显示出显著的变化 (p < 0.05).
- 尿液中的V-ATPase亚基C1降低,IKBIP增加,与微专蛋白相关.
- 蛋白质水平在对照组,T2DM和DN组之间有显著差异,这表明了DN相关性.
结论:
- 减少V-ATPase亚基C1和增加尿液中的IKBIP与DN密切相关.
- 这些蛋白质作为预测DN风险的生物标志物在诊断时表现有前途.
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