在一生中保持大脑健康
Isabel García-García1, Olga Donica2, Armand Aaron Cohen3
1Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Centre for Research in Neurosciences, Lausanne University Hospital, University of Lausanne, Switzerland; Clinique la Prairie, Montreux, Switzerland.
Neuroscience and biobehavioral reviews
|August 21, 2023
概括
健康的衰老取决于管理影响身体和大脑的终身因素. 针对饮食,运动,睡眠和炎症的干预措施可以促进健康的大脑衰老,并保持老年人的功能.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 衰老的轨迹有很大的不同,从脆弱到功能维护.
- 了解影响衰老的终身因素对于开发干预措施至关重要.
- 老年时的大脑健康受到许多外部和内部因素的影响.
研究的目的:
- 提供关于影响大脑健康的终身因素的综合文献概述.
- 探索衰老风险因素的机制和相互作用.
- 讨论目前减轻这些风险因素的策略.
主要方法:
- 对关于衰老,大脑健康和风险因素的研究进行文献评论.
- 对生活方式和健康因素的累积和渐进影响的分析.
- 综合关于健康衰老干预措施的证据.
主要成果:
- 不健康的饮食,久坐不动的行为,睡眠问题,心血管风险和炎症累计损害大脑健康.
- 这些因素相互作用,影响衰老中的身体,认知和社会功能.
- 及时干预可以抵消风险因素,促进成功的衰老.
结论:
- 可修改的风险因素在整个生命周期中显著影响大脑健康.
- 个性化,多领域策略是保持大脑健康的关键.
- 对风险因素的洞察力可以为老龄化人口的干预提供信息.
相关概念视频
Cognitive Development During Adulthood
155
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
155
Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86
The Blood-brain Barrier
47.5K
Overview
47.5K
Neuroplasticity
567
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
567
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Neurogenesis and Regeneration of Nervous Tissue
858
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
858


