通过使用威尔士语的常规可用的数据集,可以建立儿童期ADHD和ASD的全国电子队列吗?
Kate Langley1, Marcos Del Pozo-Banos2,3, Søren Daalsgard4,5,6
1School of Psychology, Cardiff University, Cardiff, UK LangleyK@cardiff.ac.uk.
BMJ open
|August 21, 2023
概括
为注意力缺陷多动症 (ADHD) 和自闭症谱系障碍 (ASD) 建立全国性的电子队列是可行的. 这种方法可以准确地识别患有多动症和自闭症的个体,在年轻人中显示出更高的心理健康问题和物质使用风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 注意缺陷多动症 (ADHD) 和自闭症谱系障碍 (ASD) 是普遍存在的神经发育状况.
- 纵向研究对于了解ADHD和ASD个体的长期结果至关重要.
- 建立大型,具有代表性的队列对于强大的流行病学研究至关重要.
研究的目的:
- 评估创建国家电子健康记录 (e-cohort) 的可行性和有效性,用于被诊断为ADHD和/或ASD的个人.
- 确定这个电子队列是否可以用于未来的纵向研究.
- 将电子队列的特征和结果与直接评估的队列进行比较.
主要方法:
- 利用了威尔士安全匿名信息链接数据库,将例行初级保健,紧急情况和住院数据联系起来.
- 在1991-2000年间出生,使用ICD-10和NHS READ代码诊断出患有ADHD/ASD的确诊个体.
- 将ADHD/ASD病例与对照进行匹配,并与直接评估的ADHD队列进行比较.
主要成果:
- 这项研究确定了7726名ADHD患者和5001名ASD患者.
- 患有ADHD的个体显著增加了焦虑/抑郁,自我伤害,酒精和药物使用以及急诊室访问的风险.
- 患有自闭症的人患有焦虑/抑郁症,自我伤害和吸毒风险更高,但酒精使用风险不高. ADHD电子队列反映了直接评估队列的结果.
结论:
- 开发的识别策略是可行的建立一个大的ADHD/ASD电子队列.
- 这一电子队列展示了早期成年期结果较差的预期模式.
- 该方法为识别纵向研究的大样本提供了有效的方法,最大限度地减少了选择性磨损.
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