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Published on: November 6, 2017
视网膜光学一致性断层扫描特征与帕金森病的发生和流行有关
Siegfried Karl Wagner1, David Romero-Bascones2, Mario Cortina-Borja2
1From the Institute of Ophthalmology (S.K.W., D.J.W., R.R.S., Y.Z., P.J.F., K.B., A.P.K., P.J.P., J.S.R., A.P., P.A.K.), University College London; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology (S.K.W., D.R.-B., D.J.W., R.R.S., Y.Z., E.K., P.J.F., K.B., A.P.K., P.J.P., J.S.R., A.K.D., A.P., P.A.K.), London, United Kingdom; Biomedical Engineering Department (D.R.-B., E.K., U.A., M.B.), Faculty of Engineering (MU-ENG), Mondragon Unibertsitatea, Spain; Great Ormond Street Institute of Child Health (M.C.-B., J.S.R.), and Centre for Medical Image Computing (D.J.W., R.R.S., Y.Z.), Department of Computer Science, University College London; NeuroMetrology Lab (S.P., C.A.A.), Nuffield Department of Clinical Neurosciences, University of Oxford; Dementia Research Centre (R.S.W.), University College London, United Kingdom; Department of Molecular Medicine (E.J.T.), Scripps Research, La Jolla, CA; Byers Eye Institute (E.K.), Stanford University, Palo Alto, CA; Biocruces Bizkaia Health Research Institute (I.G.), Barakaldo; IKERBASQUE: The Basque Foundation for Science (I.G.), Bilbao, Spain; Department of Clinical and Movement Neurosciences (A.H.V.S.), UCL Queen Square Institute of Neurology; Great Ormond Street Hospital NHS Foundation Trust (J.S.R.); Ulverscroft Vision Research Group (J.S.R.), University College London; NIHR Biomedical Research Centre at UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital (J.S.R.), London; University of Birmingham (A.K.D.); University Hospitals Birmingham NHS Foundation Trust (A.K.D.); NIHR Birmingham Biomedical Research Centre (A.K.D.), University of Birmingham; and Queen Square Institute of Neurology (A.P.), University College London, United Kingdom. s.wagner@ucl.ac.uk.
内核层 (INL) 和状细胞内层 (GCIPL) 的视网膜稀薄与帕金森病 (PD) 有关. 这一发现表明光学连贯断层扫描 (OCT) 可能有助于早期发现PD和风险分层.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 尸体研究表明,在帕金森病 (PD) 中,视网膜神经退行.
- 使用光学相干断层扫描 (OCT) 在体内检测这些视网膜变化仍在调查中.
- 内视网膜解剖学可以作为PD的生物标志物.
研究的目的:
- 使用OCT在患有PD的个体中调查视网膜内部解剖学.
- 评估视网膜标记物与潜在队列中事件PD发展之间的关联.
主要方法:
- 对两个队列的横截面分析:AlzEye (回顾性,流行PD) 和英国生物银行 (前性,事件PD).
- 使用OCT成像测量黄斑视网膜神经纤维层 (mRNFL),状细胞内层 (GCIPL) 和内核层 (INL) 厚度.
- 统计模型 (线性混合效应和脆弱模型) 用于分析关联.
主要成果:
- 与对照人群相比,患有PD的个体显示GCIPL和INL显著较薄.
- 较薄的GCIPL和INL与潜在队列中发生事件PD的风险增加有关.
- 这些视网膜变化在临床PD诊断前几年就可检测到.
结论:
- 帕金森病与视网膜的INL和GCIPL的厚度降低有关.
- 视网膜成像,特别是OCT,显示了PD早期风险分层的潜力.
- 这些发现强调了视网膜内部作为PD潜在生物标志物的作用.
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