从二氧化碳中制造出六氧化物的新人工合成
Jiangang Yang1, Wan Song2, Tao Cai1
1Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Haihe Laboratory of Synthetic Biology, Tianjin 300308, China; National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
Science bulletin
|August 21, 2023
概括
科学家们开发了一种新的化学酶方法,将二氧化碳 (CO2) 和 (H2) 转化为糖,为饮食糖生产提供一种可持续的替代方案,并应对气候变化的挑战.
科学领域:
- 生物技术和合成生物学
- 化学工程是化学工程的重要组成部分.
- 可持续化学 可持续化学
背景情况:
- 越来越多的饮食糖的需求面临着土地稀缺和气候变化的挑战.
- 目前用于将二氧化碳转化为复杂碳水化合物的方法是能源密集且低效的.
- 需要可持续的平台,从二氧化碳 (CO2) 中生产糖.
研究的目的:
- 开发一个高效的化学酶平台,从二氧化碳和H2中合成糖.
- 为了克服在二氧化碳到糖路径中的反选择性转化,能源消耗和产品多样性的挑战.
- 建立一个热力学驱动和立体控制的合成路线.
主要方法:
- 利用一种化学酶路线图,涉及阿尔多尔凝结,异构/表皮化和脱化反应.
- 工程酶催化剂,以优化热力学驱动的合成.
- 开发了一个最小的腺三酸盐 (ATP) 消耗途径,用于果糖-6-酸盐生物合成.
主要成果:
- 通过完美的立体控制,实现了不对称的CO2和H2组装成糖.
- 合成的果糖-6-酸盐具有最小的ATP消耗和最短的通路.
- 在高位数 (63 mmol L-1) 和二氧化碳转化率 (25 mmol C L-1 h-1) 的葡萄糖和D-素等生产的功能性六氧化物.
- 与传统的二氧化碳转糖工艺相比,碳转化产量更高.
结论:
- 开发的化学酶平台为从CO2中合成糖提供了一种多功能和高效的方法.
- 这种方法为传统糖生产提供了可持续的替代方案,减轻了气候变化的影响.
- 该平台的模块化允许合成各种高阶糖和CO2衍生物.
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