在高风险职业人口中,两剂BBIBP-CorV疫苗诱导的免疫持久性的预测因素
Tian Yao1, Yana Guo2, Xiuyang Xu2
1First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Vaccine
|August 21, 2023
概括
接种BBIBP-CorV疫苗的免疫保护在10个月内减弱,老年男性和没有先前接种流感疫苗的人的抗体水平下降速度更快. 开发了一种预测性名录,以评估长期免疫持久性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 随着时间的推移,免疫保护可能会随着中和抗体水平的下降而减弱.
- BBIBP-CorV疫苗的长期疗效需要了解抗体持久性.
- 预测免疫力下降对于公共卫生战略至关重要.
研究的目的:
- 开发一种名谱来预测BBIBP-CorV疫苗两剂接种后的长期免疫持续性.
- 计算中和抗体下降在个体中的概率.
- 确定影响抗体水平维持10个月的因素.
主要方法:
- 一组809名参与者在不同的时间表 (0+14,0+21,或0+28天) 中接种了两剂BBIBP-CorV疫苗.
- 中和抗体标位在第28天被测量,并在3,6个月和10个月后进行跟踪.
- 用多变量考克斯回归和诺莫格拉姆模型来确定抗体水平维持的预测因素.
主要成果:
- 共有744名参与者完成了为期10个月的随访.
- 年龄≥50岁与失去中和抗体反应的更高风险相关 (标位<16).
- 0-28天计划组的参与者,有流感疫苗接种史的人和女性显示出更好的免疫持久性.
结论:
- 中和抗体水平从BBIBP-CorV疫苗接种后的28天大幅下降到10个月.
- 诸如男性性别,50岁以上的年龄,0-14天的疫苗接种计划和缺乏流感疫苗接种史等因素与更快的抗体下降有关.
- 开发的名图表显示了适度的歧视和良好的校准来预测免疫持久性.
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