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帕金森病的亚thalamic核DBS的频率设置:一个系统的审查和网络元分析

Rajiv Dharnipragada¹, Lalitha S Denduluri², Anant Naik³

¹University of Minnesota Medical School, University of Minnesota Twin-Cities, Minneapolis, MN, 55455, USA.

Parkinsonism & related disorders

|August 21, 2023

概括

在不对药物反应的帕金森病患者中,高频刺激 (HFS) 用于脑下核深度大脑刺激 (STN-DBS) 比低频刺激 (LFS) 更能改善运动症状. 当与药物相结合时,LFS显示有好处.

科学领域:

神经外科手术神经外科手术
运动障碍运动障碍
神经科学是一个神经科学.

背景情况:

深度脑刺激 (DBS) 是对帕金森病 (PD) 运动症状的关键治疗方法.
脑下细胞核 (STN) 领先位置是PD中DBS的标准.
通过统一帕金森病评级尺度III (UPDRS-III) 来衡量STN-DBS的有效性.

研究的目的:

为了比较STN-DBS中不同频率设置的有效性.
评估高频刺激 (HFS) 与低频刺激 (LFS) 的STN-DBS疗效.

主要方法:

一个PRISMA引导的随机对照试验系统审查和元分析.
提取的UPDRS-III结果和刺激参数 (HFS ≥100 Hz,LFS <100 Hz). 在此过程中,
使用Mantle-Haenszel方法进行频率主义网络元分析,以组合赔率比率.

主要成果:

分析了15项涉及298名患者的研究.
与双边LFS相比,双边HFS显示出更高的UPDRS-III分数.
药物治疗的双边LFS显示出比药物治疗的HFS更好的结果.

结论:

双边HFS对没有药物反应的帕金森病患者更有效.
当与药物一起使用时,LFS提供了附加的好处,针对不同的症状.
不同的神经生理机制是STN-DBS中HFS和LFS的基础.

关键词:

深度大脑刺激是什么?帕金森病的疾病.亚体体内核的细胞核

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