在小鼠insula-amygdala电路中,将情绪价值和焦虑联系起来
1Neurocentre Magendie, INSERM 1215, Université de Bordeaux, Bordeaux, France.
Nature communications
|August 21, 2023
概括
焦虑障碍会改变岛内皮层 (IC) 的反应. 研究人员发现前部IC神经元跟踪焦虑水平并对负面刺激做出反应,将IC与焦虑和价值处理联系起来.
科学领域:
- 神经科学是一个神经科学.
- 焦虑症 焦虑症 研究 研究
- 行为神经科学 行为神经科学
背景情况:
- 焦虑障碍与岛内皮层 (IC) 和杏仁核中的反应变化有关.
- 通过IC神经元编码焦虑和情绪价值的神经机制仍然不清楚.
研究的目的:
- 研究IC投射神经元在编码焦虑和价值的作用.
- 在焦虑中探索IC和底侧杏仁体 (BLA) 之间的功能连接.
主要方法:
- 在小鼠中进行纤维光度记录,以测量IC中的神经活动.
- 实体电生理学来描述IC-BLA连接.
- 投影特异性光遗传学来操纵aIC-BLA神经元活动.
主要成果:
- 前部IC (aIC) 投射神经元在焦虑环境中选择性地增加了活动,与焦虑水平成比例.
- aIC神经元对积极和消极的价值刺激做出了反应,更强的负价值反应与焦虑相关.
- aIC-BLA神经元表现出焦虑性质,并被焦虑性空间和厌恶性刺激激活.
结论:
- 在aIC-BLA途径中确定了一种常见的神经生物学基质,该基质将负价值和焦虑联系起来.
- 这一途径为理解和治疗与焦虑相关的精神疾病提供了潜在的目标.
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