在有功能性体征综合征的患者中报告负面影响诱导的身体症状的脑中介
Katleen Bogaerts1,2, Maaike Van Den Houte3,4,5, Daniëlle Jongen4,5
1REVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. katleen.bogaerts@uhasselt.be.
Translational psychiatry
|August 21, 2023
概括
负面情绪会使功能性体征综合征 (FSS) 的身体症状恶化,如纤维肌痛和IBS. 脑部扫描显示,在FSS患者看到负面图像时,他们的感觉和疼痛处理能力提高,这解释了这种联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 功能性体征综合征 (FSS),包括纤维肌痛和刺激性肠综合征 (IBS),以身体症状为特征.
- 负面的情绪刺激可以加剧FSS患者的身体症状.
研究的目的:
- 在FSS中研究将负面影响与身体症状联系起来的神经机制.
- 在观看情感图像时,比较FSS患者和健康对照者之间的大脑激活模式.
主要方法:
- 功能性MRI (fMRI) 用于扫描30名FSS患者和30名健康对照 (女性).
- 参与者观看中性,积极和消极的情感图片块,并评价他们的情感和身体症状.
- 分析了整个大脑的激活,神经疼痛特征 (NPS),刺激强度独立的疼痛特征 (SIIPS) 和图像诱导的负面情绪特征 (PINES).
主要成果:
- 与对照人群相比,FSS患者在观看负图片和中性图片后报告了显著更多的身体症状.
- 在消极图像观看期间,患者在体感官区域表现出更大的激活.
- 在FSS患者中,在负相比中性图像查看和部分介导的症状报告期间,差异性NPS反应更高.
结论:
- 由视觉刺激引发的负面影响,通过激活体感和知觉大脑通路,加剧了FSS中的身体症状.
- 处理体质信号的情感驱动的改变是FSS的一个关键机制.
- 神经性疼痛特征在FSS中负面影响和身体症状之间的联系中发挥着作用.
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