相关实验视频
Updated: Jul 18, 2025
07:58
Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
13.9K
泌尿病学的生物信息学 - - 病理生理学的分子特征和对治疗的反应
Ali Hashemi Gheinani1,2,3,4,5, Jina Kim6,7,8, Sungyong You6,7,8
1Department of Urology, Boston Children's Hospital, Boston, MA, USA.
Nature reviews. Urology
|August 21, 2023
概括
生物信息学通过揭示疾病洞察力并使精确治疗成为可能,改变了医学. 诸如成本和工作流集成等挑战阻碍了其广泛的临床采用,特别是在泌尿器科.
科学领域:
- 生物信息学和计算生物学
- 基因组学和分子医学
- 泌尿病学和临床信息学
背景情况:
- 在过去的二十年里,生物信息学显著地推进了医疗实践.
- 通过生物信息学的高维数据分析已经阐明了包括癌症在内的各种疾病的分子基础.
- 像"癌症基因组图谱"这样的倡议利用生物信息学来深入了解分子.
研究的目的:
- 审查生物信息学对医疗实践,疾病亚型和个性化医学的影响.
- 识别阻碍泌尿器科先进生物信息学工具广泛临床应用的障碍.
- 建议加速生物信息学在常规临床环境中的整合的途径.
主要方法:
- 审查生物信息学在医学研究和临床实践中的应用.
- 分析计算方法,包括人工智能和机器学习.
- 检查与临床环境中的成本,工作流程和验证相关的挑战.
主要成果:
- 生物信息学已经使得疾病亚型,风险因素,生物标志物和药物重用机会的识别成为可能.
- 它在指导精确和个性化医学的发展方面发挥了重要作用.
- 尽管有好处,但先进的计算方法尚未成为泌尿病学实践中的标准.
结论:
- 生物信息学为疾病机制提供了深刻的见解,并促进了个性化的治疗策略.
- 诸如成本,工作流程中断和未来验证的需求等障碍阻碍了泌尿病学中的临床采用.
- 克服这些挑战对于将生物信息学纳入常规泌尿器科护理至关重要.
更多相关视频
13:19Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
16.6K
11:47Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
2.3K
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
13
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
13