电化学选择性电极用于量化多佐胺在散装药物物质和剂量形式中的量化
Mai M Mora1, Nahla S Ismail1, Hala E Zaazaa2
1Egyptian Drug Authority (EDA), Giza, Egypt.
BMC chemistry
|August 22, 2023
概括
为精确量化多佐胺化物 (DRZ) 开发了三种新型碳糊电极. 修改后的电极对药物配方中的DRZ具有出色的选择性和敏感性.
科学领域:
- 分析化学 分析化学
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
背景情况:
- 多尔佐胺化物 (DRZ) 是治疗青光眼的关键药物.
- 准确量化DRZ对于药品质量控制至关重要.
- 现有的分析方法可能缺乏选择性或需要复杂的程序.
研究的目的:
- 开发和验证用于多佐胺化物 (DRZ) 量化的新型碳糊电极.
- 为了研究包含和β-cyclodextrin的修改电极的性能.
- 评估药物配方中电极的选择性和适用性.
主要方法:
- 三种碳糊电极的制造:传统的,改性和β-环氧改性.
- 使用聚酸和迪布甲酸形成一个电活性多佐胺-聚酸离子交换器.
- 电位测量测量以评估电极性能,包括Nernstian响应和检测极限.
- 测试对常见干扰物的选择性,如无机离子,蒂莫洛尔酸盐和化.
- 用于在眼药眼滴中确定DRZ的改电极的应用.
主要成果:
- 所有制造的电极都表现出Nernstian反应和线性度范围.
- 电极显示了DRZ的低检测极限.
- 在存在潜在干扰物的情况下,可以选择性地确定DRZ.
- 经过改的电极在眼科眼滴样本中成功量化了DRZ.
- 当与其他报告的方法进行验证时,获得的结果是可比的和令人满意的.
结论:
- 开发的碳糊电极,特别是改版,为DRZ量化提供了可靠和选择性的方法.
- 这些电极为DRZ的制药分析提供了灵敏而高效的分析工具.
- 该研究强调了改性碳糊电极在复杂矩阵中确定活性药物成分的潜力.
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