双向纳米脂质体改善瘤微环境的抗炎免疫调节
Zili Gu1, Candido G da Silva1, Sen Ma2
1Department of Radiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Advanced healthcare materials
|August 22, 2023
概括
这项研究开发了一种新型的脂质体组合,该组合是胺二二氧化酶 (IDO) 抑制剂和卡博桑提尼布. 这种双重向治疗有效抑制瘤生长,并逆转免疫抑制瘤微环境.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米医学是一种纳米医学.
背景情况:
- 癌症免疫疗法,包括胺2,3-二氧化酶 (IDO) 抑制剂,显示出希望,但单独具有有限的临床益处.
- 卡博桑提尼布是一种氨酸激酶抑制剂,具有免疫调节作用,但单一疗法的有效性有限.
- 瘤微环境通常具有免疫抑制作用,阻碍有效的抗癌免疫反应.
研究的目的:
- 为IDO抑制剂 (IDO-IN-7) 和卡博桑提尼布开发一种新型的脂质体共递系统.
- 评估这种联合治疗在抑制瘤生长和调节瘤微环境方面的疗效.
- 评估这种双重向纳米药物在未来临床应用中的潜力.
主要方法:
- 同时封装IDO-IN-7和cabozantinib进入脂质体,以增强瘤积累和减少副作用.
- 细胞毒性和IDO酶抑制的体外评估.
- 在体内评估瘤生长抑制和免疫细胞在瘤微环境中的概况.
主要成果:
- 脂质体组合显示出强大的细胞毒性和有效的IDO抑制.
- 双重向治疗显著抑制了瘤的发展.
- 该疗法逆转了抑制性瘤微环境,增加了T细胞和B细胞的透,减少了调控性T细胞,促进了M1类瘤相关的巨细胞,增加了中性粒细胞.
结论:
- 这种由脂质体输送的IDO抑制剂和卡博桑提尼布的组合代表了一种新且有前途的抗癌策略.
- 双重向的方法有效调节瘤微环境中的适应性和先天性免疫力.
- 这种配方在未来的癌症治疗中具有显著的临床转化潜力.
更多相关视频
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.6K
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.8K
相关概念视频
01:27Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K